Journal article
CT perfusion imaging in response assessment of pulmonary metastases undergoing stereotactic ablative radiotherapy
B Sawyer, E Pun, M Samuel, H Tay, T Kron, M Bressel, D Ball, S Siva
Journal of Medical Imaging and Radiation Oncology | Published : 2015
Abstract
Introduction Stereotactic ablative body radiotherapy (SABR) is an emerging treatment technique for pulmonary metastases in which conventional Response Evaluation Criteria in Solid Tumours (RECIST) may be inadequate. This study aims to assess the utility of CT perfusion imaging in response assessment of pulmonary metastases after SABR. Methods In this ethics board-approved prospective study, 11 patients underwent a 26-Gy single fraction of SABR to pulmonary metastases. CT perfusion imaging occurred prior to and at 14 and 70 days post-SABR. Blood flow (mL/100 mL/min), blood volume (mL/100 mL), time to peak (seconds) and surface permeability (mL/100 mL/min), perfusion parameters of pulmonary me..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We would like to thank Mr Jim Cramb, Director of Physical Sciences, for the initial evaluation of the CT perfusion technique, and Mr Alan Herschtal, Senior Biostatistician, for statistical input into the SAFRON trial. Dr Shankar Siva has received National Health and Medical Research Council scholarship funding for research associated with this work, APP1038399.